Vaginal rejuvenation is a term that has reached a great popularity between doctors and women over the last few years. Commonly speaking this is referred to cosmetic procedures aiming to improve the aspects of female genitalia secondary to changes related to age or vaginal deliveries. Many important scientific Societies and Authorities have delivered documents warning about the paucity of evidence in such procedures that should also produce and improvement in quality of life and sexual function. Etymologically, however, vaginal rejuvenation could be part of regenerative medicine including not surgical procedures but medical or outpatient approaches. Tissue remodelling can be nowadays stimulated in a regenerative way in different organs with a great scientific interest in different medical fields. In this lecture all controversies and the most recent knoledeges will be illustrated in relation to vaginal rejuvenation.