Uterine Transplantation is a reality but who, how and when? (2527)
Absolute uterine factor infertility (AUFI) represents 5% of infertile women and is the only untreatable subgroup of female infertility. It is due to absence of the uterus (congenital or hysterectomy) or the presence of a non-functional uterus. The only two options for a woman with AUFI to become mother today are through a gestational surrogate mother or adoption; both procedures are prohibited in many countries and not without several legal and ethical concerns. Uterus transplantation (UTx) presents a potential future treatment of AUFI. After extensive animal research over the last 15 years, also involving non-human primates, a small number of human UTx cases have recently been performed in Sweden. Here, I summarize our primate UTx experiments that have paved the way for our “nine” human UTx cases, resulting in “five” healthy babies. The estimate number for potential candidates and the ethics around UTx are also addressed.